首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.
Authors:E Y Jones  S J Davis  A F Williams  K Harlos  D I Stuart
Institution:Laboratory of Molecular Biophysics, Oxford, UK.
Abstract:The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号