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Effect of dibutyryl cyclic AMP and analogs on the rate of contractions of myocytes in culture
Authors:K. Nath  A. P. Bollon
Affiliation:(1) Department of Biochemistry, University of Texas, Health Science Center, 75235 Dallas, Texas, USA;(2) Present address: Merck Institute for Therapeutic Research, P.O.B. 2000, 07065 Rahway, New Jersey, USA
Abstract:Summary 2O,6N-butyryl, 3prime, 5prime-cyclic monophosphate (dibu cAMP) when added to fetal rat heart cells in culture inhibits myocyte contraction. This inhibition is 100, 84 and 51% complete when the dibu cAMP concentration used is 2, 0.2 and 0.02 mM, respectively. The potency of dibu cAMP derivatives in myocyte contraction inhibition follows the order, dibu cAMP>6N-bu cAMP>2O-bu cAMP=AMP>butyrate. The inhibition caused by the first three chemicals is greater than 70%.The author was a Moss Heart Fellow and acknowledges the technical assistance of Ms Martha Peet. This work was supported in part by the American Heart Association, National Science Foundation and American Cancer Society.
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