| 双嘧达莫嵌段共聚物胶束的制备及体外药物释放 |
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| 引用本文： | 张娜,郭圣荣.双嘧达莫嵌段共聚物胶束的制备及体外药物释放[J].河北大学学报(自然科学版),2010,30(6). |
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| 作者姓名： | 张娜 郭圣荣 |
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| 基金项目： | 河北省自然科学基金，河北大学自然科学研究博士项目 |
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| 摘 要： | 以聚癸二酸酐-聚乙二醇-聚癸二酸酐为载体材料,采用沉淀/溶剂挥发法制备双嘧达莫载药胶束,DLS法测定胶束的粒径,紫外分光光度法测定胶束的载药量、包封率和药物的释放度.结果发现载药胶束的粒径大于空白胶束的粒径;随着共聚物中疏水链段比例的增加,胶束的载药量和包封率都上升,而且药物释放时间延长;调节嵌段共聚物的链段组成,可以调节药物的释放动力学过程.
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| 关 键 词： | 双嘧达莫 嵌段共聚物 胶束 药物释放 |
Preparation of Dipyridamole Block Copolymer Micelle and Research of in Vitro Drug Release |
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| ZHANG Na,GUO Sheng-rong.Preparation of Dipyridamole Block Copolymer Micelle and Research of in Vitro Drug Release[J].Journal of Hebei University (Natural Science Edition),2010,30(6). |
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| Authors: | ZHANG Na GUO Sheng-rong |
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| Abstract: | The dipyridamole drug-loaded micelle was prepared with a novel block copolymer poly(sebacic anhydride)-poly(ethylene glycol)-poly(sebacic anhydride) by precipitation/solvent evaporation method.The diameter of micelle was measured by DLS.The UV-VIS method was used to study the drug loaded,drug-loading efficiency,and release rate of the dipyridamole micelle.The diameter of drug-loaded micelle was found larger than the corresponding drug-free micelle.The drug loaded and drug-loading efficiency increased with the increase of hydrophobic block in copolymer,as well as the drug release time.Different dipyridamole release profiles could be obtained with adjusting the composition of the block copolymers. |
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| Keywords: | dipyridamole block copolymer micelle drug delivery |
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