| 人乳头瘤病毒16L1抗血清的制备和鉴定 |
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| 引用本文： | 董金蓉,谢飞,刘勇,郭仁,彭建新,刘红岩. 人乳头瘤病毒16L1抗血清的制备和鉴定[J]. 华中师范大学学报(自然科学版), 2007, 41(1): 99-101 |
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| 作者姓名： | 董金蓉 谢飞 刘勇 郭仁 彭建新 刘红岩 |
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| 作者单位： | 华中师范大学,生命科学学院,武汉,430079;中国疾病预防控制中心,病毒免疫室,北京,100179;云南沃森生物技术有限公司,昆明,650118 |
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| 摘 要： | 人乳头瘤病毒16型是导致宫颈癌发生的主要因素,其晚期蛋白L1在体内或体外可自组装形成VLP颗粒.作者构建了DNA疫苗载体pDRVI1.0-16L1,大提质粒后免疫BalB/C小鼠制备抗体,并对抗体进行了特异性鉴定,为HPV16L1预防性疫苗的进一步研究和应用奠定了基础.
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| 关 键 词： | 人乳头瘤病毒16L1 抗血清 制备 鉴定 |
| 文章编号： | 1000-1190（2007）01-0099-03 |
| 修稿时间： | 2006-10-25 |
Preparation and identification of the antibody to human papillomavirus 16L1 |
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| DONG Jinrong,XIE Fei,LIU Yong,GUO Ren,PENG Jianxin,LIU Hongyan. Preparation and identification of the antibody to human papillomavirus 16L1[J]. Journal of Central China Normal University(Natural Sciences), 2007, 41(1): 99-101 |
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| Authors: | DONG Jinrong XIE Fei LIU Yong GUO Ren PENG Jianxin LIU Hongyan |
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| Affiliation: | 1. College of Life Science, Huazhong Normal University,Wuhan 430079; 2. Yunnan Walvax Bio-Tech Limited Compang, Kunming 630118; 3. Division of Research on Virdogy and Immunology, Chinese Center for Disease Control and Prevention, Beijing 100179 |
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| Abstract: | Human papillomavirus 16 is the main factor inducing uterine cervix cancer. The late protein L1 can form the virus-like particles in vivo or vitro spontaneously. We constructed a DNA vaccine vector pDRVI1.0-16L1 and prepared the antibody by immunizing BalB/c mice. Also we have identified its specificity and layed a good foundation on the study and application for prophylactic vaccine for human papillomavirus 16L1. |
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| Keywords: | HPV16L1 antibody preparation identification |
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