Different marrow cell number requirements for the haemopoietic colony formation and the cure of the W/Wv anemia |
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| Authors: | W. Wiktor-Jedrzejczak C. Szczylik P. Górnaś S. J. Sharkis A. Ahmed |
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| Affiliation: | (1) Laboratory for Radiation, Immunohaematology, Postgraduate Center, Military School of Medicine, ul. Szaserów 128, 00-909 Warsaw, (Poland);(2) The Johns Hopkins Oncology Center, 21205 Baltimore, Maryland, USA;(3) The Naval Medical Research Institute, 20014 Bethesda, Maryland, USA |
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| Abstract: | Summary The lowest cell number in the normal marrow transplant, which allows the cure of W/Wv anemia was found to be between 104 and 105. This exceeds by several times the lowest cell number necessary for the haemopoietic colony formation. Therefore, either the colony forming cell is not the haemopoietic stem cell but rather its progeny, or this cell requires an aid from some other cells to exert its activity.Acknowledgments. We are indebted to Doc. Dr Maksymilian Siekierzynski for his help and advice and to Miss Elzbieta Szewczyk for expert technical assistance. |
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