Stimulation of histamine synthesis in rat mast cells by compound 48/80 in vitro |
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Authors: | A M Rothschild I C Fortunato |
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Institution: | (1) Department of Pharmacology, School of Medicine of Ribeirão Preto, USP, 14100 Ribeirão Preto, SP., Brazil |
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Abstract: | Summary The histamine content of rat peritoneal fluid cells is doubled within 20 min by 0.5 g/ml of compound 48/80. Histamine catabolism inhibitors do not reproduce this effect; cells pre-incubated with -fluoromethylhistidine are unresponsive to compound 48/80 which therefore activates pre-formed histidine decarboxylase rather than inducing it. Non-mast cells showed no change after treatment with compound 48/80. |
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Keywords: | Rat mast cells histamine synthesis compound 48/80 |
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