The site of 25-hydroxycholecalciferol stimulated protein synthesis in the rat kidney |
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| Authors: | M Cochran |
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| Institution: | (1) University Department of Medicine, Renal Unit, Royal Hospital, S1 3SR Sheffield, (England);(2) Present address: Department of Medicine, Flinders Medical Centre, 5042 Bedford Park, (South Australia) |
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| Abstract: | Summary Autoradiographs of the kidneys of rachitic rats dosed in vivo with 250 pmoles 25-hydroxycholecaliferol (25-OHD3) and3H-leucine showed increased grain counts in portions of proximal renal tubules. On incubation of kidney slices the synthesis of only 1 cytosol protein was found to be stimulated by the steroid. On disc gel electrophoresis it had the characteristics of renal calcium binding protein. |
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