| H_8-NOBIN-脯氨酰胺有机催化不对称直接Aldol反应 |
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| 引用本文： | 吕旭初,刘全忠,郭川胜. H_8-NOBIN-脯氨酰胺有机催化不对称直接Aldol反应[J]. 西华师范大学学报(哲学社会科学版), 2008, 29(2): 177-181 |
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| 作者姓名： | 吕旭初 刘全忠 郭川胜 |
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| 作者单位： | 西华师范大学化学化工学院,四川南充637002 |
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| 摘 要： | 以光活性H8-NOBIN和N-叔丁氧羰基-L-脯氨酸为原料合成了2个脯氨酰胺。该脯氨酰胺与三氟乙酸组合可有效催化芳香醛和酮的不对称直接Aldol反应．催化芳香醛和丙酮的反应化学产率最高达76％，对映体过量值达83％；催化对硝基苯甲醛和环己酮的反应化学产率高达98％，非对映选择性达88：12，反式异构体对映体过量值达90％．
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| 关 键 词： | 脯氨酰胺 有机催化 不对称 Aldol反应 |
H_8-NOBIN-Prolinamide Catalyzed Asymmetric Direct Aldol Reaction |
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| LU Xu-chu,LIU Quan-zhong,GUO Chuan-sheng. H_8-NOBIN-Prolinamide Catalyzed Asymmetric Direct Aldol Reaction[J]. Journal of China West Normal University:Natural Science Edition, 2008, 29(2): 177-181 |
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| Authors: | LU Xu-chu LIU Quan-zhong GUO Chuan-sheng |
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| Affiliation: | LU Xu-chu,LIU Quan-zhong,GUO Chuan-sheng(College of Chemistry , Chemical Engineering,China West Normal University,Nanchong 637002,China) |
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| Abstract: | An enantioselective Aldol reaction was catalyzed by prolinamides synthesized from optically pure binaphthol and H8-NOBIN.Aldehydes were reacted with ketones affording the corresponding product in up to 98% yield and with up to 90% ee. |
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| Keywords: | prolinamide organocatalysis asymmetric Aldol reaction |
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