Frequency-dependent effect of verapamil on rat soleus muscle |
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Authors: | B A Kotsias S Muchnik |
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Institution: | (1) Instituto de Investigaciones Médicas, Donato Alvarez 3150, 1427 Buenos Aires, Argentina |
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Abstract: | Summary In the presence of verapamil (0.1 mM) rat soleus muscle fibers failed to generate action potentials with overshoots. In fibers with their Vm set to a local level of –90 mV, verapamil produces a gradual reduction in the amplitude of the repetitive action potentials; this effect is more pronounced at high rates of stimulation (100 Hz). Our results suggest a local anesthetic action of this drug that could contribute with its calcium channel blocking effect to the diminished mechanical tension observed in the presence of the drug.Acknowledgments. We thank A. Losavio and M. Stefanolo for technical assistance. This work was supported by grants from CONICET and SUBCYT, Buenos Aires, Argentina and Muscular Dystrophy Association, USA. |
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Keywords: | Rat skeletal muscle verapamil frequency-dependent effect mechanical activity electrical activity |
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