Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis |
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Authors: | A Scutt S Meghji J P Canniff W Harvey |
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Institution: | (1) Department of Oral & Maxillo-Facial Surgery, Institute of Dental Surgery, Eastman Dental Hospital, 256 Gray's Inn Road, WC1X8LD London, (England) |
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Abstract: | Summary Treatment of reconstituted collagen fibrils and pieces of rat dermis with the crude extract, purified tannins or (+)-catechin from betel nut (Areca catechu) increases their resistance to both human and bacterial collagenases in a concentration-dependent manner. These tanning agents may stabilise collagen in vivo following damage to the oral epithelium and promote the sub-epithelial fibrosis which occurs in betel nut chewers. |
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Keywords: | Collagen oral submucous fibrosis tannins flavanoids collagenase |
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