| 聚N-异丙基丙烯酰胺水凝胶的微波合成及其药物控释性研究 |
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| 引用本文： | 张建州,卢艳霞,谢建刚,毛海荣. 聚N-异丙基丙烯酰胺水凝胶的微波合成及其药物控释性研究[J]. 河南科学, 2008, 26(9) |
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| 作者姓名： | 张建州 卢艳霞 谢建刚 毛海荣 |
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| 作者单位： | 1. 郑州师范高等专科学校化学系,郑州,450044
2. 郑州师范高等专科学校化学系,郑州,450044;东华大学化学化工与生物工程学院,上海,201620 |
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| 基金项目： | 河南省科技厅科技攻关项目 |
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| 摘 要： | 用微波引发合成了聚N-异丙基丙烯酰胺,并制成整体型释放器,对非水溶性药物阿昔洛韦在不同温度响应时的药物缓释行为进行了研究.
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| 关 键 词： | 聚N-异丙基丙烯酰胺 阿昔洛韦 微波 药物控释 |
Studies on Synthesis of Poly(N-Isoproprylacrylamide) Thermo-Responsive Hydrogels by Microwave and Vitro Release |
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| Zhang Jianzhou,Lu Yanxia,Xie Jiangang,Mao Hairong. Studies on Synthesis of Poly(N-Isoproprylacrylamide) Thermo-Responsive Hydrogels by Microwave and Vitro Release[J]. Henan Science, 2008, 26(9) |
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| Authors: | Zhang Jianzhou Lu Yanxia Xie Jiangang Mao Hairong |
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| Affiliation: | Zhang Jianzhou1,Lu Yanxia1,Xie Jiangang1,2,Mao Hairong1 (1. Department of Chemistry,Zhengzhou Teachers College,Zhengzhou 450044,China,2. College of Chemistry,Chemical Engineering , Biotechnology,Donghua University,Shanghai 201620,China) |
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| Abstract: | Fast responsive thermosensitive PNIPA hydrogels were synthesized by using free radical polymerization in microwave oven. Such hydrogels swelled or shrank same fast in response to the chang of temperature as conven-tional hydrogels. Acyclovir is a broad-spectrum antivirus. PNIPA hydrogel with acyclovir was tested for drug release. It was identified that hydrogel as drug matrixes could deliver longer and more validly. |
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| Keywords: | poly(N-Isoproprylacrylamide) acyclovir microwave controlled drug-release |
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