Study of ionizable drugs transfer across the water/1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system |
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作者姓名: | ZHANGMeiqin SUNPeng CHENYong LIFei GAOZhao SHAOYuanhua |
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作者单位: | [1]StateKeyLaboratoryofElectroanalyticalChemistry,ChangchunInstituteofAppliedChemistry,ChineseAcademyofSciences,Changchun130022,China [2]CollegeofChemistryandMolecularEngineering,PekingUniversity,Beijing100871,China |
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摘 要: | The electrochemical behavior of ionizable drugs (Amitripty/ine, Diphenhydramine and Trihexyphenedyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r=Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCI disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ionizable drugs transfer process at a liquid/liquid interface.Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard partition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The obtained results have been summarized in ionic partition diagrams, which are a useful tool for predicting and interpreting the transfer mechanisms of ionizable drugs at the liquid/liquid interfaces and biological membranes.
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关 键 词: | 电离药物转移 水 1,2-二氯乙烷 三电极系统 电化学行为 界面化学 ITIES 非互溶电解液 |
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