Diphasic action of 2,2-diphenylpropionic acid N,N-diethylaminoethyl ester hydrochloride on hepatic drug metabolism in the mouse

Summary 2,2-Diphenylpropionic acid N,N-diethylaminoethyl ester hydrochloride, 30 min after a single i.p. dose, inhibits the microsomal drug-metabolizing enzymes of the mouse liver and prolongs the hexobarbital sleeping time; 24 h after the administration, it induces hepatic microsomal drug-metabolizing enzymes and shortens hexobarbital sleeping time.