| 预测竞争性和非竞争性剪接位点对 |
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| 引用本文： | 杨乌日吐,李前忠,林昊,杨科利.预测竞争性和非竞争性剪接位点对[J].内蒙古大学学报(自然科学版),2008,39(3):294-299. |
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| 作者姓名： | 杨乌日吐 李前忠 林昊 杨科利 |
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| 作者单位： | 内蒙古大学物理科学与技术学院,呼和浩特,010021 |
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| 基金项目： | 国家自然科学基金
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内蒙古自然科学基金
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内蒙古优秀学科带头人项目 |
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| 摘 要： | 基于剪接位点竞争机制,剪接位点对分成竞争性剪接位点对和非竞争性剪接位点对.并且竞争性和非竞争性剪接位点对的分类是一个很重要的工作.结合位置权重矩阵、离散量和支持向量机,提出了预测竞争性和非竞争性剪接位点对的新方法.独立检验集中90%以上的剪接位点对能被正确地分类成竞争性和非竞争性剪接位点对.此预测成功率高于其它方法.
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| 关 键 词： | 竞争性剪接位点对 非竞争性剪接位点对 支持向量机 competitive splice site pair non-competitive splice site pair support vector machine |
| 文章编号： | 1000-1638(2008)03-0294-06 |
| 修稿时间： | 2007年10月10 |
Prediction of Competitive and Non-Competitive Splice Site Pairs |
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| YANG Wu-ri-tu,LI Qian-zhong,LIN Hao,YANG Ke-li.Prediction of Competitive and Non-Competitive Splice Site Pairs[J].Acta Scientiarum Naturalium Universitatis Neimongol,2008,39(3):294-299. |
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| Authors: | YANG Wu-ri-tu LI Qian-zhong LIN Hao YANG Ke-li |
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| Abstract: | Based on the mechanism of splice site competition, splice site pairs are divided into competitive splice site pairs and non-competitive splice site pairs, and the classification of competitive and non-competitive splice site pairs is an important task. The support vector machine method which combines with position weight matrix and increment of diversity is proposed for predicting competitive and non-competitive splice site pairs. The predictive results for the independent testing sets show that more than 90% of the splice site pairs are correctly classified into competitive and non-competitive. While compared with recent method, the predictive capability and reliability are improved by using our method. |
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| Keywords: | competitive splice site pair non-competitive splice site pair support vector machine |
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