If phosphatases go up, memory goes down |
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Authors: | G Riedel |
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Institution: | (1) University of Aberdeen, Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD (UK), Fax +44 1224 273019, e-mail: g.riedel@abdn.ac.uk, UK |
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Abstract: | Previous work has provided conclusive support for a role of various protein kinases in processes underlying learning and
memory formation. While these processes are not yet established in full detail, it is interesting to entertain the idea of
protein phosphatases being involved in such mechanisms as well. Recent advances in this respect have provided preliminary
support of this view. From the pharmacological as well as the transgenic analysis, it appears that especially the calcineurin/inhibitor-1
cascade plays an important role in the transition of intermediate-term into long-term memory formation. |
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Keywords: | , Hippocampus, synaptic plasticity, memory formation, protein kinase A, protein phosphatase 1 and 2A, calcineurin, |
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