|
|||||
|
|
Recombinant human PDCD5 protein enhances chemo-sensitivities of hematologic malignancies |
|
| Authors: | YanFang Wang Lin Shi QuanSheng Song YingMei Zhang YaXin Lou Yi Zheng DaLong Ma Ying Wang XiaoYan Ke |
| Institution: | 1 Department of Hematology, Peking University Third Hospital, Beijing 100191, China; 2 Peking University Center for Human Disease Genomics, Beijing 100191, China; 3 Department of Medical Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; 4 Peking University Medical and Health Analysis Center, Peking University Health Science Center, Beijing 100191, China |
| Abstract: | PDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and As2O3 in three hematologic tumor cell lines. In vivo stud-ies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xeno-graft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemothera-peutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemo-sensitizer. |
| Keywords: | hematologic malignancies PDCD5 apoptosis chemotherapy chemosensitivity |
| 本文献已被 维普 SpringerLink 等数据库收录！ | |
| 点击此处可从《中国科学通报(英文版)》浏览原始摘要信息 | |
| 点击此处可从《中国科学通报(英文版)》下载免费的PDF全文 | |