The Three-component One-pot Synthesis of 4,6-Diarylpyrimidin-2(1h)-ones and 9-Phenyl-8-oxa-10,12-diaza-tricyclo[7.3.1.0~(2,7)]trideca-2(7),3,5-trien-11-one |
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Authors: | F.Derikvand M.M.Heravi L.Ranjbar |
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Affiliation: | Department of Chemistry School of sciences Azzahra University Department of Chemistry School of sciences Vanak Tehran Iran |
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Abstract: | 1 Results Pyrimidinones (PMs) are a class of important heterocycles which have been well documented throughout the literature due to their biological importance. They exhibit a wide range of pharmaceutical and therapeutic properties[1].A rapid and efficient one-pot method for the synthesis of 4,6-diarylpyrimidin-2(1H)- ones and related heterocycles is described.The condensation of acetophenone derivatives,aldehydes and urea in the presence of sulfamic acid was employed to synthesize a variety of pyrimid... |
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Keywords: | diarylopyrimidinones solvent-free reactions sulfamic acid multi-component reactions |
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