血必净注射液对严重多发伤患者凝血功能及预后的影响

目的：研究血必净注射液对严重多发伤患者凝血功能的影响，探讨其对预后的影响。方法：将78例严重多发伤患者随机分为2组，对照组42例给予常规综合治疗，治疗组36例在对照组治疗基础上早期加用血必净注射液，分别检测2组治疗前、治疗后14d的血小板计数、凝血酶原时间、活化部分凝血活酶时间，同时记录2组患者的急性生理和慢性健康状况（APACHE）Ⅲ评分；观察2组14d死亡率。结果：治疗组于治疗14d后上述检测指标改善且与对照组比较有显著性差异；2组APACHEⅢ评分均较治疗前下降且治疗14d后治疗组较对照组下降明显；治疗组较对照组死亡率低但差异无显著性。结论：早期应用血必净注射液对严重多发伤患者凝血功能有良性调节作用，从而在一定程度上改善预后。

Effects of Xuebijing Injection on Severe Multiple Trauma Patients' Coagulation Function and Orognosis

Objective： To study the Xuebijing injection on severe multiple trauma patients＇ coagulation function, and to explore its effects on prognosis. Methods： 78 cases of severe multiple trauma patients were randomly divided into two groups. The control group of 42 cases were given conventional treatment, and the treatment group of 36 cases were treated with Xuebijing injection. 14 days before and after treatment, the platelet count, prothrombin time, activated partial thromboplastin time were measured, and the acute physiology and chronic health evaluation （APACHE） Ⅲ in two groups were recorded. Mortality after 14 days was observed. Results： The detection indicators of the treatment group 14 days after treatment improved and compared with the control group there were significant differences. In the two groups APACHE Ⅲ score before treatment declined, 14 days after treatment the treatment group decreased more significantly than the control group. The treatment group mortality rate was lower than the control group but the difference was not statistically significant. Conclusions： Immediate using of Xuebijing injection for severe multiple trauma patients had benign regulatory role to a certain extent, and improved the prognosis.