Enclomiphene induces luteolysis in the nonpregnant guinea pig |
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Authors: | P. K. Wesfahl |
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Affiliation: | (1) Department of Zoology, Miami University, 45056 Oxford, Ohio, USA;(2) Present address: California College of Podiatric Medicine, 1210 Scott St., 94115 San Francisco, CA, USA |
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Abstract: | Summary The effect of two antiestrogens, enclomiphene and tamoxifen, on luteal function in the guinea pig was compared to that of estradiol, a known luteolysin. Enclomiphene caused premature luteolysis when administered during the early or mid-luteal phase of the cycle, but was not as potent as estradiol. Tamoxifen had no effect. The luteolytic effect of enclomiphene was mediated by the uterus, as has been shown for estradiol. |
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Keywords: | Enclomiphene luteolysis guinea pig |
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