Increased urinary excretion of cyclic nucleotides in X-linked hypophosphatemic (Hyp) mice |
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Authors: | G. M. Kiebzak R. A. Meyer Jr P. M. Mish |
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Affiliation: | (1) Department of Basic Sciences, School of Dentistry, Marquette University, 604 North 16th Street, 53233 Milwaukee, WI, USA |
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Abstract: | Summary Hyp mice, a model for human X-linked hypophosphatemia, had elevated urinary cyclic AMP, cyclic GMP, and magnesium excretion compared to normal mice. The data suggest a renal origin of the urinary cyclic nucleotides. No significant differences in plasma cyclic AMP and cyclic GMP were observed between genotypes.This work was supported in part by research grants from The Kroc Foundation and the NIH, RR-09016. |
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