| 苯基哌嗪类多巴胺D3受体配体的合成 |
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| 引用本文： | 顾莉洁. 苯基哌嗪类多巴胺D3受体配体的合成[J]. 海南师范大学学报(自然科学版), 2007, 20(4): 342-345 |
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| 作者姓名： | 顾莉洁 |
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| 作者单位： | 江苏省徐州医药高等职业学校,江苏,徐州,221116 |
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| 基金项目： | 国家自然科学基金项目(30472011) |
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| 摘 要： | 以二羟乙基胺为起始原料,经过氯化、环合、取代、肼解、缩合等反应,合成了6个苯基哌嗪类多巴胺D3受体配体.结构经红外(IR)、质谱(MS)、核磁氢谱(1HNMR)和元素分析(EA)确证,合成的6个目标化合物均未见文献报道.并以BP897为阳性药,对所合成的化合物进行了初步药理实验研究.
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| 关 键 词： | 多巴胺D3受体配体 苯基哌嗪类化合物 化学合成 |
| 文章编号： | 1671-8747(2007)04-0342-04 |
| 修稿时间： | 2007-09-25 |
Synthesis of phenylpiperazino compounds as dopamine D3 receptor ligands |
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| Gu Lijie. Synthesis of phenylpiperazino compounds as dopamine D3 receptor ligands[J]. Journal of Hainan Normal University:Natural Science, 2007, 20(4): 342-345 |
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| Authors: | Gu Lijie |
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| Abstract: | Starting from diethanolamine,compounds were prepared via chlorination,cyclization,substitution,aminolysis and condensation reaction,and six phenylpiperazino compounds such as Dopamine D3 Receptor ligands were synthesized.The structures of these compounds were identified by IR,MS,1HNMR,and EA,and the 6 synthesized compounds had never been reported before.The preliminary pharmacological tests were carried out on these compounds. |
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| Keywords: | dopamine D3 receptor ligand phenylpiperazino compound chemical synthesis |
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