Relationship between the temperature and the acoustic nonlinearity parameter in biological tissues

Recently with the rapid development of the high-intensity focused ultrasound (HIFU) in biomedical ul- trasound, much attention has been paid to the noninvasive temperature estimation in biological tissue in order to de- termine the region and degree of the ultrasound-induced lesions. In ultrasound hyperthermal therapy it is highly de- sirable to study the real-time noninvasive monitoring of temperature distribution in biological tissue. In this paper, the relationship between the nonlinearity parameter B/A and the temperature in biological tissue is studied and compared with the theoretical model as well as the experimental results from the thermocouple. Results indicated that B/A could be used as an effective tool to monitor the temperature distribu- tion in biological media.