| 3-(2,4,5-三乙氧基苯甲酰)—丙酸的合成研究 |
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| 引用本文： | 陈亚萍.3-(2,4,5-三乙氧基苯甲酰)—丙酸的合成研究[J].高师理科学刊,2003,23(4):39-41. |
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| 作者姓名： | 陈亚萍 |
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| 作者单位： | 江阴职业技术学院,化工系,江苏,江阴,214433 |
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| 摘 要： | 3- ( 2 ,4,5 -三乙氧基苯甲酰 )—丙酸是治疗胆囊炎和胆囊结石的新型药物 ,在对其进行结构分析后确定以对苯醌为起始原料 ,通过乙酰化反应、乙基化反应、付克酰基化反应合成本品 ,在付克酰基化反应实验过程中对工艺条件进行改革 ,并有所突破 ,大大提高了产品收率 .产物分子结构用元素分析、红外光谱 (IR)、核磁共振谱 ( 1HNMR)进行了表征 .
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| 关 键 词： | 3-(2 4 5-三乙氧基苯甲酰)—丙酸 乙基化反应 付克酰基化反应 合成 |
| 文章编号： | 1007-9831(2003)04-0039-03 |
| 修稿时间： | 2003年6月26日 |
Study on the synthesis of 3-(2,4,5-triethoxy benzoyl)- propoic acid |
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| CHEN Ya-ping.Study on the synthesis of 3-(2,4,5-triethoxy benzoyl)- propoic acid[J].Journal of Science of Teachers＇College and University,2003,23(4):39-41. |
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| Authors: | CHEN Ya-ping |
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| Abstract: | The reaction of quinone and acetic anthyride under the catalysting of H_2SO_4 has been studied, and the product1,3,4-triethyl bezoate is reacted with Et_2SO_4 catalysted by CH_3OH/NaOH, and 1,3,4-triethoxy.Benzoate is obtained.The product 3-(2,4,5-triethoxy benzoyl)-propoic acid is obtained through 1,3,4-triethoxy benzoate reacting with acetic anthydride.And its chemical structure has been confirmed by elemental analysis,IR, 1H-NMR . |
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| Keywords: | 3-(2 4 5-triethoxy benzoyl)-propoic acid ethylation F-K reaction synthesis |
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