| 环肽Ascidiacyclamide异构体的合成 |
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| 引用本文： | 简志刚 蹇敦龙. 环肽Ascidiacyclamide异构体的合成[J]. 中山大学学报(自然科学版), 1992, 31(2): 57-61 |
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| 作者姓名： | 简志刚 蹇敦龙 |
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| 作者单位： | 中山大学化学系，中山大学化学系，中山大学化学系 |
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| 摘 要： | 从缬氨酸,L-丝氨酸,L-苏氨酸,L-异亮氨酸出发合成了海洋环肽Ascidiacy-clamide的异构体cyclo-[-D,L-(Val)Thz-L-Ser-L-Ile-D,L-(Val)Thz-L-Thr-L-Ile-]-。其中噻唑氨基酸由Hantzsch方法合成,肽链由DCC-HOBT(DCC即二环己基碳化二亚胺,dicyclohexylcarbodimide;HOBT即1-羟基合水苯并噻唑,1-hydroxybenzotria-zolenydrate)缩合而形成。关大环采用叠氮方法。
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| 关 键 词： | 海洋环肽 抗肿瘤活性 噻唑 合成 |
Synthesis of the Isomer of Cyclopeptide Ascidiacyclamide |
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| Jian Zhigang,Jian Dunlong,Long Kanghou. Synthesis of the Isomer of Cyclopeptide Ascidiacyclamide[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 1992, 31(2): 57-61 |
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| Authors: | Jian Zhigang Jian Dunlong Long Kanghou |
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| Affiliation: | Jian Zhigang;Jian Dunlong;Long Kanghou Department of Chemistry |
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| Abstract: | The cyclopeptide DL-(Val)T hz-L-Ser-L-Ile L-Ile-L-Thr-DL-(ValThz,an isomer of marine cyclopeptide Ascidiacyclamide has been synthesized. The rhiazole amino acid was prepared by Hantzsch method. The peptide bonds were constructed by DCC-HOBT coupling method and the peptide ring was formed by azide method. |
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| Keywords: | cyclopeptide thiazole antineoplastic activity synthesis |
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