A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides |
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| Authors: | R J Deshaies B D Koch M Werner-Washburne E A Craig R Schekman |
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| Institution: | Department of Biochemistry, University of California, Berkeley 94720. |
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| Abstract: | Depletion of a subset of 70K stress proteins in yeast mutants shows that they are involved in the post-translational import of precursor polypeptides into both mitochondria and the lumen of the endoplasmic reticulum. The identification of such a basic function may explain the remarkable evolutionary conservation of the gene family encoding these proteins. |
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