Pentobarbital-induced phase shifts of circadian rhythms of locomotor activity are not mediated through stimulated activity in mice |
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Authors: | S Ebihara H Hayakawa |
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Institution: | (1) Department of Animal Physiology, Faculty of Agriculture, Nagoya University, 464 Chikusa, Nagoya, (Japan) |
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Abstract: | Summary The possibility that phase shifts of circadian rhythms of locomotor activity induced by pentobarbital injections are mediated through hyperactivity after recovery from the sedative condition was tested in DBA/2 mice. The mice were restrained for 3 h in a tube immediately after injections of pentobarbital at either CT 9 or CT 0. The results indicated that immobilization did not block the phase shifts, suggesting that pentobarbital-induced phase shifts are not due to increasing the level of activity. |
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Keywords: | Circadian rhythms pentobarbital phase shifts mice immobilization hyperactivity |
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