| 蛇床子素固体分散体的制备与分析 |
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| 引用本文： | 李宝红,张立坚,庄海旗,东野广智,邓亦峰,梁念慈. 蛇床子素固体分散体的制备与分析[J]. 华东理工大学学报(自然科学版), 2004, 30(5): 598-600 |
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| 作者姓名： | 李宝红 张立坚 庄海旗 东野广智 邓亦峰 梁念慈 |
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| 作者单位： | 广东医学院广东天然药物研究与开发重点实验室,湛江,524023;广东医学院分析中心;广东医学院化学教研室 |
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| 基金项目： | 广东医学院青年基金(XQ0209) |
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| 摘 要： | 应用聚乙烯吡咯烷酮(PVP)为载体，采用溶剂挥发法制备了蛇床子素(OSL)的固体分散体，测定了OSL原料药、固体分散体以及机械混合物的体外溶解度，并通过扫描电镜观察、红外光谱以及紫外光谱分析对固体分散体进行了研究，结果表明，OSL固体分散物的溶解度与OSL原料药和机械混合物相比有明显提高；OSL分子和载体分子之间未发生化学变化。
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| 关 键 词： | 蛇床子素 聚乙烯吡咯烷酮 溶剂法 固体分散体 溶解度 |
| 文章编号： | 1006-3080(2004)05-0598-03 |
| 修稿时间： | 2003-10-30 |
Preparation and Analysis of Solid Dispersion of Osthole |
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| LI Bao-hong,ZHANG Li-jian,ZHUANG Hai-qi,DONGYE Guang-zhi,DENG Yi-feng,LIANG Nian-ciMedical College,Zhanjiang ,China, . Center Laboratory of Guangdong Medical College. Preparation and Analysis of Solid Dispersion of Osthole[J]. Journal of East China University of Science and Technology, 2004, 30(5): 598-600 |
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| Authors: | LI Bao-hong ZHANG Li-jian ZHUANG Hai-qi DONGYE Guang-zhi DENG Yi-feng LIANG Nian-ciMedical College Zhanjiang China . Center Laboratory of Guangdong Medical College |
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| Affiliation: | LI Bao-hong~1*,ZHANG Li-jian~2,ZHUANG Hai-qi~3,DONGYE Guang-zhi~2,DENG Yi-feng~1,LIANG Nian-ci~1Medical College,Zhanjiang 524023,China, 2. Center Laboratory of Guangdong Medical College, 3. Department of Chemistry of Guangdong Medical College) |
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| Abstract: | Using poly(vinylpyrrolidone) as a carrier, solid dispersions of osthole were prepared by solvent method. The dissolution of the solid dispersion was detected with the use of scanning electron microscope, IR spectrometer and UV spectrometer results showed that in contrast with the osthole and the physical mixtures of osthole and carrier the dissoluation of solid dispersion was significantly increased. These was no chemical reaction between osthole and carrier. |
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| Keywords: | osthole poly(vinylpyrrolidone) solvent method solid dispersions dissolvability |
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