嗜黏蛋白阿克曼菌对急性高尿酸血症小鼠尿酸及肝肾功能的影响

目的 研究嗜黏蛋白阿克曼菌(Akkermansia muciniphila)对急性高尿酸血症小鼠尿酸及肝肾功能的影响.方法 连续灌胃7d给予小鼠氧嗪酸钾制备急性高尿酸血症模型,以别嘌呤醇为阳性对照药,检测A.muciniphila灌胃7d对血清尿酸(UA)、肌酐(Crea)、尿素氮(BUN)、谷丙转氨酶(ALT)、谷草...

Effect ofAkkermansia muciniphilaon Uric Acid,Liver and Kidney Function in Mice with Acute Hyperuricemia

Abstract: Objective To explore the effect of Akkermansia muciniphila on uric acid, liver and kidney function in mice with acute hyperuricemia. Method The acute hyperuricemia model was prepared by gavage of potassium oxonate in mice for one week. Allopurinol was used as the positive control drug. The levels of serum uric acid ( UA) , creatinine ( Crea ) , urea nitrogen ( BUN ) , alanine aminotransferase ( ALT ) , aspartate aminotransferase( AST) and γ-glutamyl transpeptidase ( GGT ) activity of hyperuricemia mice after one week gavage of A. muciniphila were measured. Result After one week gavage of A. muciniphila, the level of serum uric acid decreased partially, but there was no significant difference ( P>0. 05) . The changes of serum Crea, BUN, ALT, AST and GGT were not obvious. Conclusion A. muciniphila had little effect on serum uric acid level and liver and kidney function in mice with acute hyperuricemia.