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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 |
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| Authors: | van Heel David A Franke Lude Hunt Karen A Gwilliam Rhian Zhernakova Alexandra Inouye Mike Wapenaar Martin C Barnardo Martin C N M Bethel Graeme Holmes Geoffrey K T Feighery Con Jewell Derek Kelleher Dermot Kumar Parveen Travis Simon Walters Julian R F Sanders David S Howdle Peter Swift Jill Playford Raymond J McLaren William M Mearin M Luisa Mulder Chris J McManus Ross McGinnis Ralph Cardon Lon R Deloukas Panos Wijmenga Cisca |
| Affiliation: | Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK. d.vanheel@qmul.ac.uk |
| Abstract: | We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. |
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