循环雌二醇及代谢物与绝经后乳腺癌的相关性

目的探讨循环雌二醇（E2）、4-羟雌二醇（4-OHE2）、2-甲氧雌二醇（2-MOE2）水平及4-羟雌二醇：2-甲氧雌二醇（4-OHE2：2-MOE2）比值与绝经后乳腺癌危险性的相关性。方法采用ELISA法检测绝经后34例乳腺癌、40例乳腺良性（乳腺纤维腺瘤与乳腺囊性增生病）疾病患者和20例正常对照循环雌二醇、4-羟雌二醇、2-甲氧雌二醇水平并计算4-羟雌二醇：2-甲氧雌二醇比值。结果乳腺癌组及乳腺良性疾病组循环2-甲氧雌二醇水平差异无统计学意义（P〉0．05），但均较正常对照组低（P〈0．05）；乳腺癌组及乳腺良性疾病组4-羟雌二醇：2、甲氧雌二醇比值差异无统计学意义（P〉0．05），但均较正常对照组升高（P〈0．05）。乳腺癌Ⅰ期～Ⅲ期各期循环雌二醇、4．羟雌二醇、2-甲氧雌二醇、4-羟雌二醇：2-甲氧雌二醇比值差异无统计学意义（P〉0．05）。4-羟雌二醇、2．甲氧雌二醇、4．羟雌二醇：2-甲氧雌二醇比值在乳腺癌ER（-）组与ER（＋）组间差异无统计学意义（P〉005），但ER（＋）组雌二醇水平较ER（-）组明显升高（P〈0．05）。结论2．甲氧雌二醇与绝经后乳腺疾病负相关；4-羟雌二醇：2-甲氧雌二醇比值可能预示绝经后乳腺疾病危险。

Correlation Between Circulating Estradiol, its Metabolites and Breast Cancer in Postmenopausal Women

Objective To study the correlation between circulating levels of estradiol （ E2 ） ,4-Hydroxyestradiol （ 4-OHE2 ）, 2-Methoxyestradiol （2-MOE2） , the ratios of 4-Hydroxyestradiol ： 2-Methoxyestradiol （ 4-OHE2 ： 2-MOE2 ） and breast cancer risk in postmenopausal women. Methods Serum levels of E2,4-OHE2,2-MOE2 were measured by ELISA methods in 34 breast caner patients,40 breast benign disease（ fibroadenoma and cystic hyperplasia）patients and 20 controls, the ratios of 4-OHE2：2-MOE2 was calculated. Results There were no significantly differences in circulating levels of 2-MOE2 between breast cancer group and breast benign disease group （P 〉 0.05 ） , but which were obviously lower than that in control group （ P 〈 0.05 ）. There were no significantly differences in the ratios of 4-OHE2 ： 2-MOE2 between breast cancer group and breast benign disease group （ P 〉 0.05 ）, but which were obviously greater than that in control group （ P 〈 0.05 ）. There were no significant differences in circulating levels of E2,2-MOE2 ,4-OHE2 and the ratios of 4-OHE2：2-MOE2 from stage I to stage m breast cancer（ P 〉 0.05 ）. Circulating levels of 4-OHE2,2-MOE2 and the ratios of 4-OHE2：2-MOE2 were not significantly different between estrogen receptor positive breast cancer group and estrogen receptor negative breast cancer group（ P 〉 0.05）. Circulating levels of E2 were obviously greater in estrogen receptor positive than that in estrogen receptor negative group （P 〈 0. 05 ）. Conclusion Circulating level of 2-MOE2 is negatively associated with breast disease and the ratio of 4-OHE2：2-MOE2 may predict breast disease risk in postmenopausa women.