慢性疼痛患者脑静息态功能磁共振的初步研究

目的采用脑静息态功能磁共振成像技术（fMRI）观察骨性关节炎慢性疼痛患者双侧丘脑腹后外侧核（ventral posterolateral nucleus VPLN）与全脑功能连接情况。方法对16名骨性关节炎慢性疼痛患者与16名健康志愿者双侧丘脑腹外侧核（VPLN）与全脑功能连通性进行脑静息态fMRI检查，使用rest1.4软件计算并分析两组受试者VPLN与全脑功能连通性的差异（激活闽值P〈0．05，像素范围〉85）。结果骨性关节炎慢性疼痛患者双侧丘脑VPLN与额叶、枕叶等脑区功能连通性存在减弱的情况，而与小脑、中脑、海马等脑区的功能连通性增强。结论慢性疼痛患者双侧VPL与感受及编码疼痛的兴奋性大脑皮层功能连通性降低，而与参与镇痛的抑制性中枢脑区的功能连通性增加。

Resting State fMRI Preliminary Study of Brain in Patents with Chronic Pain

Objective To investigate how the functional connectivitys between ventral posterolateral nucleus （VPL） and the rest of the brain alteres after years of ongoing osteoarthritis by the resting-state functional MRI （ fMRI）. Methods 16 osteoarthritis patients and 16 normal subjects matched controls underwent examination in resting-state with fMRI. VPL were the regions of interest, and the difference of OA patients between controls Was analyzed with two-sample t-test by restl. 4. Results Compared with controls. The patient group showed decreased resting state functional connectivity between the VPL and the cortex （frontal, occipital lobe） , and increased resting state functional connectivity of cerebral areas （Cerebellar, periaqueductal gray, hippoeampus）. Conclusion IN the OA patients there is an increased connectivity of cerebral areas related to inhibitory control of pain,and a reduced connectivity of feelings and excitement of the cerebral cortex encode pain.