Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus. |
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| Authors: | H Acha-Orbea A N Shakhov L Scarpellino E Kolb V Müller A Vessaz-Shaw R Fuchs K Bl?chlinger P Rollini J Billotte |
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| Institution: | Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland. |
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| Abstract: | Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus. |
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