| NMDA受体概述及其在学习记忆中的作用 |
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| 引用本文： | 柯珂,乔琰,王俊.NMDA受体概述及其在学习记忆中的作用[J].广西科学院学报,2011,27(1):49-54. |
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| 作者姓名： | 柯珂 乔琰 王俊 |
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| 作者单位： | 1. 广西科学院,广西南宁,530007
2. 广西化工研究院,广西南宁,530001 |
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| 摘 要： | NMDA受体是由多亚基构成的异聚体,是最重要的谷氨酸受体之一,主要分布在中枢系统中.NMDA受体有多个调节位点,能被谷氨酸、甘氨酸、Ca2+、酶等多种因素影响.NMDA受体介导的Ca2+内流广泛地参与多种生理作用,其引发的长时程增强作用而对学习记忆有极其重要的作用.
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| 关 键 词： | NMDA受体 学习 记忆 长时程增强 |
| 收稿时间： | 2010/9/26 0:00:00 |
The General Situation of NMDA Receptor and Its Role in Learning and Memory |
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| KE Ke,QIAO Yan and WANG Jun.The General Situation of NMDA Receptor and Its Role in Learning and Memory[J].Journal of Guangxi Academy of Sciences,2011,27(1):49-54. |
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| Authors: | KE Ke QIAO Yan and WANG Jun |
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| Institution: | 1.Guangxi Academy of Sciences,Nanning,Guangxi,530007,China;2.Guangxi Research Institute of Chemical Industry,Nanning,Guangxi,530001,China) |
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| Abstract: | NMDA receptor,which is composed with multisubunits,is the one of the most important glutamate receptors,mainly distributed in the central nervous system.Due to many regulating sites of this receptor,it could be affected by glutamic acid,glycin,Ca2+,some enzymes and so on.Calcium influx which is mediated by NMDA receptor is involed in variety physiological actions.LTP,which is induced by one of the actions,plays an important role in learning and memory. |
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| Keywords: | NMDA receptor learning memory LTP |
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