| 膀胱癌NMP22检测的临床病例对照研究 |
| |
| 引用本文： | 郭晓,王剑松,刘靖宇,徐鸿毅.膀胱癌NMP22检测的临床病例对照研究[J].大理学院学报,2004,3(1):20-23. |
| |
| 作者姓名： | 郭晓 王剑松 刘靖宇 徐鸿毅 |
| |
| 作者单位： | 1. 大理学院附属医院泌尿外科,云南大理,671000
2. 昆明医学院第二附属医院泌尿外科,云南昆明,65010 |
| |
| 摘 要： | 目的 :探索NMP22(核基质蛋白22)在膀胱癌诊断和术后监测的作用。方法:采用临床流行病学病例对照研究方法进行研究。应用美国Matritech公司提供的NMP22试剂盒检测40例膀胱癌尿液中的NMP22含量。结果 :以美国FDA的诊断参考值10U/ml为标准 ,本次研究的敏感性为100% ,特异性为65 %。病例组性别及各个年龄组的NMP22无显著性差异 (P>0.05)。病例组中的膀胱癌不同分级及分期的NMP22含量比较差异有高度显著性 (P<0.001) ,膀胱癌是否复发的NMP22差异有高度显著性 (P<0.001)。结论:NMP22检测技术具有敏感性高 ,无创伤 ,可定量分析等优点 ,可以作为诊断膀胱癌和术后监测的一个指标。
|
| 关 键 词： | 膀胱癌 核基质蛋白22 病例对照研究 |
| 文章编号： | 1672-2345(2004)01-0020-04 |
| 修稿时间： | 2003年9月3日 |
A Clinical Case - control Study of NMP22 for Detection of Bladder Cancer |
| |
| GUO Xiao ,WANG Jian-song ,LIUJin-yu ,et al.A Clinical Case - control Study of NMP22 for Detection of Bladder Cancer[J].Journal of Dali University,2004,3(1):20-23. |
| |
| Authors: | GUO Xiao WANG Jian-song LIUJin-yu |
| |
| Institution: | GUO Xiao 1,WANG Jian-song 2,LIUJin-yu 2,et al |
| |
| Abstract: | Objective:To evaluate the clinical use of NMP22for the diagno sis and surveillance of bladder cancer.Methods:This study was undergone with the clinical case-control study of epideniology.The level of NMP22was measured in the urine of40patients with bladder cancer using the NMP22Test Kit(Matritech,Co).Results:According to the diagnosis standard of USA FDA(10U/ml),the sensitivity and specificity of NMP22for the diagnosis of bladder cancer was100%and65%,respectively.The level of NMP22was evaluated with the increasing of pathological grade and stage(P<0.01).The value in recurrent cases was significantly higher than those in original cases(P<0.01).The value of NMP22of male,female and at different age in cases with bladder cancer is not significant difference(P>0.05).Conclusions:Urinary NMP22is a simple,noninvasive,sensitive test for the diagnosis and surveillance of bladder cancer. |
| |
| Keywords: | Bladder cancer Nuclear matrix protein 22 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
