Effect of aldosterone and methylprednisolone on cardiac NaK-ATPase |
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Authors: | C. Hegyvary |
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Affiliation: | (1) Departments of Medicine and Physiology, Rush University Medical College, 60612 Chicago, Illinois, USA |
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Abstract: | Summary Aldosterone (15 g BID) and methylprednisolone (8 mg QD) administration to female guinea-pigs augmented both the total and the specific activity of NaK-ATPase but not the activity of adenylate cyclase in the cardiac sarcolemma. The rise in NaK-ATPase was due to increase in the number of enzyme molecules; catalytic activity and ouabain-sensitivity of individual molecules did not change.Acknowledgments. This work was supported by grant 1 R01 HL16611 from the National Heart and Lung Institute of the National Institutes of Health, United States Public Health Service. I thank Mr Kooil Kang for his excellent technical assistance. |
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