Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in <Emphasis Type="Italic">Aplysia</Emphasis> |
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Authors: | Email author" target="_blank">Romuald?NargeotEmail author John?Simmers |
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Institution: | 1.Laboratoire Mouvement, Adaptation, Cognition, Université Bordeaux 2, CNRS UMR 5227,Bordeaux,France |
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Abstract: | Associative learning in goal-directed behaviors, in contrast to reflexive behaviors, can alter processes of decision-making
in the selection of appropriate action and its initiation, thereby enabling animals, including humans, to gain a predictive
understanding of their external environment. In the mollusc Aplysia, recent studies on appetitive operant conditioning in which the animal learns about the positive consequences of its behavior
have provided insights into this form of associative learning which, although ubiquitous, remains mechanistically poorly understood.
The findings support increasing evidence that central circuit- and cell-wide sites other than chemical synaptic connections,
including electrical coupling and membrane conductances controlling intrinsic neuronal excitability and underlying voltage-dependent
plateauing or oscillatory mechanisms, may serve as the neural substrates for behavioral plasticity resulting from operant
conditioning. Aplysia therefore continues to provide a model system for understanding learning and memory formation that enables establishing the
neurobiological links between behavioral, network, and cellular levels of analysis. |
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Keywords: | |
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