The role of sialic acid in 5-HT binding to synaptic membranes |
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| Authors: | G A Dette W Wesemann |
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| Institution: | (1) Abteilung Neurochemie, Physiologisch-chemisches Institut, Philipps-Universität, D-3550 Marbur/Lahn, Lahnberge, Federal Republic of Germany |
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| Abstract: | Summary The high affinity binding of 14C]5-HT to nerve ending membranes isolated from rat brain is not affected by neuraminidase treatment. The specificity of ligand receptor interaction was demonstrated by displacement studies with tryptamine derivatives, noradrenaline, and acetylcholine.The expert technical assistance of Miss Christiane von Winterfeld is appreciated. This work was supported by a grant of the Deutsche Forschungsgemeinschaft. |
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