Effect of hyperphenylalaninemia on polyphosphoinositides content of rat brain |
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| Authors: | A. K. Dwivedy S. N. Shah |
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| Affiliation: | (1) Langley Porter Psychiatric Institute, Brain-Behavior Research Center at Sonoma Developmental Center, University of California San Francisco, 95431 Eldridge, California, USA;(2) Present address: A.R.C. Unit of Invertebrate Chemistry and Physiology, Dept. of Zoology, University of Cambridge, Downing Street, CB2 3 EJ Cambridge, UK |
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| Abstract: | Summary Hyperphnylalaninemia (experimental PKU) induced in developing rats by treatment with p-chlorophenylalanine (PCPA) plus phenylalanine (PHE) causes a significant reduction in the triphosphoinositide (TPI) and diphosphoinositide (DPI) content of brain. Since TPI and DPI play an important role in excitable nervous membranes, the functional abnormality in experimental and perhaps in genetic PKU may be related to the reduction in TPI and DPI content.This work was supported by research grant NS14938 from National Institutes of Health. |
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