艾拉莫德对脂多糖诱导的小鼠系统性炎症的保护作用

研究艾拉莫德对脂多糖(LPS)诱导的小鼠系统性炎症和多器官损伤的保护作用。小鼠腹腔注射LPS 5 mg/kg建立系统性炎症和多器官损伤模型。试验结果显示,与模型组相比,阳性药强的松组(prednisone)和T614中高剂量组动物死亡率、临床症状、脏器系数及组织病理学结果均显著改善;同时血液生化指标(ALT、AST、ALP、BUN、CREA和UA)显著降低(均P0.01),血液学指标(WBC、RBC、PLT和RET)均与空白对照组动物水平相当。试验结果表明T614对LPS诱导的小鼠系统性炎症和多器官损伤具有保护作用。

Iguratimod diminishes LPS-induced systemic inflammation in mice

To investigate the protective effect of Iguratimod(T614) against lipopolysaccharide(LPS) induced systemic inflammation and multiple organ damage in mice. We established a systemic inflammation and multiple organ damage mouse model by intraperitoneal injection LPS 5 mg/kg. The results showed the death rate, clinical symptoms, organ index and histopathological findings of positive drug control group (prednisone) 5 mg/kg and T614 30 mg/kg and 90 mg/kg dose groups were improved obviously than the model group. The blood biochemical parameters (ALT, AST, ALP, BUN, CREA and UA) were lower obviously than the model group(P<0.01), the hematological parameters(WBC, RBC, PLT and RET) were in the same level comparing with the blank control group. The results showed T614 diminishes LPS-induced systemic inflammation and multiple organ damage in mice.