| FLN用于N~+-K~+-ATP酶活力与取代芳烃分子结构的相关性研究(英文) |
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| 引用本文： | 印春生 李志良. FLN用于N~+-K~+-ATP酶活力与取代芳烃分子结构的相关性研究(英文)[J]. 吉首大学学报(自然科学版), 1999, 20(4): 1-6 |
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| 作者姓名： | 印春生 李志良 |
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| 作者单位： | [1]中国科学技术大学应用化学系,安徽合肥 [2]湖南大学化学工业学院,湖南长沙 |
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| 基金项目： | SupportedbyNSFC!(No .2 97750 0 1)，MMIF，FYTF |
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| 摘 要： | 运用一种新型的无隐含层的人工神经网络———函数连接型网络研究了 38种取代芳烃化合物的分子结构———毒性的定量相关关系 ,计算表明 :函数连接型网络预测结果更为精确和可靠 ,计算结果与实验值之间的相关系数为 0 .956 1～ 0 .9996 ,比多元线性回归结果要好 ,后者的相关系数为 0 .86 9～ 0 .96 5
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| 关 键 词： | 函数连接型函数 Na~+-K~+酶活性 QSAR 取代芳烃 MLR |
Application of Artificial NeuralNetwork:Na~+-K~+-ATPase Activity With Structure of Substituted Aromatic Compounds |
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| YIN Chun-sheng ,GAO Wei-min ,WU Kong-dao ,PAN Zhong-xiao ,LI Zhi-liang ,,ZHANG Mao-sen. Application of Artificial NeuralNetwork:Na~+-K~+-ATPase Activity With Structure of Substituted Aromatic Compounds[J]. Journal of Jishou University(Natural Science Edition), 1999, 20(4): 1-6 |
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| Authors: | YIN Chun-sheng GAO Wei-min WU Kong-dao PAN Zhong-xiao LI Zhi-liang ZHANG Mao-sen |
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| Affiliation: | YIN Chun-sheng 1,GAO Wei-min 1,WU Kong-dao 1,PAN Zhong-xiao 1,LI Zhi-liang 1,2,ZHANG Mao-sen 1 |
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| Abstract: | Systematic studies were made on the applications of the functional-link net(FLN),a novel single-layer neural network,without hidden neurons,to the relationship between the Na +-K + adenosine trphosphatase activities and the chemical structures of substituted aromatic learning rule is used in FLN.By comparing the FLN with multiple linear regression models(MLR),it was found that the former behaves better than the latter.The correlation coefficient,0.956 1～0.999 6,of the results obtained by FLN is better than that of the results obtained by MLR,0.869～0.965.Furthermore,the convergence speed of FLN is faster than the backpropagation algorithm. |
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| Keywords: | functional-link net Na +-K +-ATPase activity substituted aromatic compounds MLR |
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