| 磁性表面手性分子印迹聚合物对氧氟沙星手性分离的研究 |
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| 引用本文： | 赵晨,孟祥艳,陆文总,武玥.磁性表面手性分子印迹聚合物对氧氟沙星手性分离的研究[J].科学技术与工程,2017,17(13). |
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| 作者姓名： | 赵晨 孟祥艳 陆文总 武玥 |
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| 作者单位： | 西安工业大学电信学院,西安工业大学电信学院,西安工业大学电信学院,西安工业大学电信学院 |
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| 基金项目： | 陕西省自然科学基础研究计划项目（2014JQ2-8053）；陕西省科技厅面上项目（2016JM8095） |
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| 摘 要： | 研究了一种可快速拆分氧氟沙星的方法;该方法采用分子印迹技术,用二氧化硅包裹的Fe3O4磁性纳米颗粒为载体,再用手性试剂N-正辛基-D-葡萄糖胺作为单体,以氧氟沙星作为模板分子制备磁性表面分子印迹聚合物。该手性聚合物可与右旋氧氟沙星结合,最终分离出左旋氧氟沙星。最后利用外加磁场及透射电子显微镜对于所制备的氧氟沙星磁性分子印迹聚合物的性状进行检测;并对分离得到的左旋氧氟沙星进行旋光度的检测。
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| 关 键 词： | 磁性颗粒 表面分子印迹 分子印迹技术 磁性表面聚合物 手性分离 |
| 收稿时间： | 2016/10/30 0:00:00 |
| 修稿时间： | 2016/12/8 0:00:00 |
Magnetic surface molecular imprinting polymer for chiral separation of ofloxacin |
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| ZHAO Chen,and.Magnetic surface molecular imprinting polymer for chiral separation of ofloxacin[J].Science Technology and Engineering,2017,17(13). |
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| Authors: | ZHAO Chen and |
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| Abstract: | The paper mainly research on a method of quickly resolving ofloxacin using molecular imprinting technique. Fe3O4 magnetic nanoparticles coated with silica is acted as the substrate. Chiral reagent is N-octyl-D-glucosamine as monomer, with ofloxacin as the template molecules to prepare magnetic surface molecularly imprinted polymer. The chiral polymer can be combined with dextral ofloxacin, eventually levofloxacin was isolated. Finally by using extermal magnetic field and transmission electron microscopy (TEM), the character of magnetic surface molecularly imprinted polymer is tested, and the levofloxacin is detected by optical rotation. |
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| Keywords: | magnetic particles surface molecular imprinting molecular imprinting technique the magnetic surface of the polymer chiral separation |
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