| 迷迭香酸的抗菌机理研究 |
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| 引用本文： | 孙峋,汪靖超,李洪涛,杜桂彩,郭道森.迷迭香酸的抗菌机理研究[J].青岛大学学报(自然科学版),2005,18(4):41-45. |
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| 作者姓名： | 孙峋 汪靖超 李洪涛 杜桂彩 郭道森 |
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| 作者单位： | 青岛大学科研处,山东,青岛,266071;青岛大学生物系,山东,青岛,266071 |
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| 基金项目： | 青岛市科技局资助项目（No.03-2-NN-2） |
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| 摘 要： | 为了了解迷迭香酸的抗菌活性及抗菌机理，采用平板生长抑制法，变性聚丙烯酰胺凝胶电泳法（SDS-PAGE），聚合酶链式反应（PCR）分析等方法，研究了迷迭香酸对大肠杆菌（Escherichia coli）和金黄色葡萄球菌（Staphylococcus aureus）的抗菌活性及其抗菌机理。结果表明，迷迭香酸对大肠杆菌和金黄色葡萄球菌均有抗菌活性，且对金黄色葡萄球菌的活性大于对大肠杆菌的活性；迷迭香酸可改变细菌细胞膜的通透性，导致还原糖和蛋白质的渗漏而影响细胞代谢，通过抑制DNA聚合酶的活性而影响DNA复制，从而发挥了抑菌作用。
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| 关 键 词： | 迷迭香酸 抗菌活性 抗菌机理 |
| 文章编号： | 1006-1037（2005）-04-0041-05 |
| 收稿时间： | 2005-08-27 |
| 修稿时间： | 2005年8月27日 |
A Study on the Antibacterial Mechanism of Rosmarinic Acid |
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| SUN Xun,WANG Jing-chao,LI Hong-tao,DU Gui-cai,GUO Dao-sen.A Study on the Antibacterial Mechanism of Rosmarinic Acid[J].Journal of Qingdao University(Natural Science Edition),2005,18(4):41-45. |
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| Authors: | SUN Xun WANG Jing-chao LI Hong-tao DU Gui-cai GUO Dao-sen |
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| Institution: | 1. Department of Scientific Research, Qingdao 266071, China; 2. Department of Biology, Qingdao University, Qingdao 266071, China |
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| Abstract: | The inhibitory activities of rosmarinic acid against Escherichia coli and Staphylococcus aureus in vitro were examined with the aim of elucidating its antibacterial mechanism. The results showed that rosmarinic acid inhibited the growths of both bacteria, but higher than that against Escherichia coli in vitro. Further nism of rosmarinic acid was associated with the effects of brane, protein metabolism and DNA replication. the activity against Staphylococcus aureus was study demonstrated that the antibacterial mecharosmarinic acid on the permeability of cell mere. |
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| Keywords: | rosmarinic acid antibacterial activity antibacterial mechanism |
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