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槟榔对动物胃肠运动的影响
引用本文:杨颖丽,程昉,王慧玲,司克媛. 槟榔对动物胃肠运动的影响[J]. 西北师范大学学报(自然科学版), 2002, 38(1): 61-63
作者姓名:杨颖丽  程昉  王慧玲  司克媛
作者单位:[1]西北师范大学生命科学学院,甘肃兰州730070 [2]山丹县第一中学,甘肃张掖734100
基金项目:西北师范大学教师科研基金项目资助 (NWNU 99 0 5 )
摘    要:从在体、离体水平观察槟榔(Areca catechu L.)对动物胃肠运动的影响,并初步探讨其作用机理。结果表明,槟榔明显增高家兔十二指肠肠管的张力,减小收缩波平均振幅,不影响收缩频率;山莨菪碱、异搏定能减弱槟榔对十二指肠肠管张力的增高作用。槟榔对小鼠胃肠推进运动有显著加强作用。由研究结果得到提示:槟榔兴奋家兔十二指肠,此效应可能由胆碱能M受体介导,且涉及家兔十二指肠平滑肌细胞膜上对异搏定敏感的Ca^2 通道。槟榔煎剂能促进小鼠胃肠推进运动。

关 键 词:槟榔 山莨菪碱 异搏定 家兔 十二指肠 M受体 肠管 张力 胃肠蠕动 药理作用
文章编号:1001-988X(2002)01-0061-03
修稿时间:2001-04-26

Effects of Areca catechu L.on gastrointestinal motility in animals
YANG Ying-li ,CHENG Fang ,WANG Hui-ling ,SI Ke-yuan. Effects of Areca catechu L.on gastrointestinal motility in animals[J]. Journal of Northwest Normal University Natural Science (Bimonthly), 2002, 38(1): 61-63
Authors:YANG Ying-li   CHENG Fang   WANG Hui-ling   SI Ke-yuan
Affiliation:YANG Ying-li 1,CHENG Fang 1,WANG Hui-ling 2,SI Ke-yuan 1
Abstract:To study the effect and mechanism of Areca catechu L.on gastrointestinal motility in vivo and vitro in animals.The results showed that:Areca catechu L.significantly increased the resting tension of duodenum in rabbits,the effect of Binglang was blocked by 654-2 and verapamil.It decreased the mean contractile amplitude,but did not affect the contractile frequency of duodenum in rabbits.Areca catechu L.increased markedly the propulsive movement of gastrointestinal tract in mice.The results suggested that,the excitatory of Areca catechu L. on the contraction of duodenum in rabbits may be mediated via M receptor and verapamil-sensitive Ca 2+ channel.Areca catechu L.has a stimulating effect on the propulsive movement of gastrointestinal tract in mice
Keywords:Areca catechu L.  654-2  verapamil  duodenum in rabbit  M receptor
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