Orange II induced cytogenetical changes in albino mice

Summary Daily feeding of the common food color Orange II to mice in doses of up to 3.0 g/kg b.wt for 180 days had deleterious effects on somatic and spermatogonial chromosomes. The chromosomal abnormalities induced were breaks, gaps, constrictions, centric fusion, fragments of unknown origin, translocation, deletion, stickiness, ring chromosomes, pyknosis and other bizarre configurations.Grateful acknowledgment is made to Prof. U.S. Srivastava, Zoology Department for providing necessary laboratory facilities.