Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia |
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| Authors: | P. Milner V. Ralevic A. M. Hopwood E. Fehér J. Lincoln K. A. Kirkpatrick G. Burnstock |
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| Affiliation: | 1. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London
2. First Department of Anatomy, Semmelweiss University Medical School, Tüzoltó u 58, H-1450, Budapest, (Hungary)
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| Abstract: | Substance P and choline acetyltransferase have been localised in a small proportion of endothelial cells of rat coronary arteries using electron microscopic immunocytochemistry. During a hypoxic period of 1 min, coronary vasodilatation was produced in the Langendorff heart preparation and increased levels of substance P and acetylcholine were released into the perfusate. The possibility that these substances are released from endothelial cells during hypoxia and contribute to the hyperaemic response is discussed. |
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| Keywords: | Heart hypoxia endothelial cells substance P acetylcholine ultrastructure |
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