| 糖尿病小鼠胰腺腺泡细胞的超微结构和酶原颗粒的定量分析 |
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| 引用本文： | 贾雪梅,齐易祥.糖尿病小鼠胰腺腺泡细胞的超微结构和酶原颗粒的定量分析[J].安徽师范大学学报(自然科学版),1995,18(2):44-47,69. |
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| 作者姓名： | 贾雪梅 齐易祥 |
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| 作者单位： | 安徽医科大学，皖南医学院 |
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| 摘 要： | 本文用四氧嘧啶将小鼠建造成糖尿病动物模型。８周后，取胰尾组织作电镜观察，对腺泡细胞的超微结构和酶原颗粒的定量分析进行了研究。结果表明：糖尿病模型小鼠胰腺腺泡细胞中粗面内质网扩张、脱颗粒；线粒体峪紊乱或断裂；胞浆内出现许多髓样小体；酶原颗粒数（Ｎ值）减少（Ｐ＜０．０１），体密度（Ｖｖ值）降低（Ｐ＜０．０１）。显示：实验性糖尿病小鼠胰腺腺泡细胞超微结构和酶原的合成受到一定程度的损害。
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| 关 键 词： | 糖尿病 胰腺 腺泡细胞 超微结构 酶原颗粒 |
Ultrastructural Study and Quantitativel Analyses of Pancreatic Acinar Cell in Moouse of Experimental Diabetes Mellitus |
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| Jia Xuemei, Qi Yixiang, Chen Shicha, Tang Jianyun.Ultrastructural Study and Quantitativel Analyses of Pancreatic Acinar Cell in Moouse of Experimental Diabetes Mellitus[J].Journal of Anhui Normal University(Natural Science Edition),1995,18(2):44-47,69. |
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| Authors: | Jia Xuemei Qi Yixiang Chen Shicha Tang Jianyun |
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| Institution: | Jia Xuemei; Qi Yixiang; Chen Shicha; Tang Jianyun(Anhui Medical University)(Department of Biology) |
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| Abstract: | The model of experimental diabetes was built with Alloxan in mouse. After eight weeks,the uItrastructure and zymogen granule of the Pancreatic acinar cell were observed and analysed by electron-microscopy.The results showed that RER Mi ap-peared morphological changes, myelia figure occurred and size and volume density of zy-mogen granule deerease(P<0. 01 ).It indicate that the experimental diabetes mellitushave damaged effect on the uItrastrueture and synthesis of zymogen in the paiicreaticacinar cell. |
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| Keywords: | Experimental diabetes mellitus zymogen granules volume density mice |
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