Suppression by LH-releasing hormone (LHRH) of the augmenting effect of estradiol on the secretion of LH and FSH by the rat pituitary gland |
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| Authors: | G A Schuiling N Pols-Valkhof T R Koiter |
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| Affiliation: | Department of Obstetrics and Gynaecology, University of Groningen, The Netherlands. |
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| Abstract: | Estradiol sensitizes the pituitary gland for the gonadotropin-releasing activity of LHRH. LHRH desensitizes the pituitary gland and does so in a dose-dependent manner. Moreover, LHRH dose-dependently suppresses the sensitizing effect of EB. In rats with an LHRH concentration in the plasma of about 90 pg/ml, the sensitizing effect of estradiol is absent. |
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