S-phase-coupled apoptosis in tumor suppression |
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Authors: | Email author" target="_blank">Yong-jig?ChoEmail author Peng?Liang |
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Institution: | (1) Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA |
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Abstract: | DNA replication is essential for accurate transmission of genomic information from parental to daughter cells. DNA replication
is licensed once per cell division cycle. This process is highly regulated by both positive and negative regulators. Over-replication,
under-replication, as well as DNA damage in a cell all induce the activation of checkpoint control pathways such as ATM/ATR,
CHK kinases, and the tumor suppressor protein p53, which provide “damage controls” via either DNA repairs or apoptosis. This
review focuses on accumulating evidence, with the emphasis on recently discovered Killin, that S-phase checkpoint control
is crucial for a mammalian cell to make a life and death decision in order to safeguard genome integrity. |
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Keywords: | |
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