| 白细胞介素24在抗肿瘤方面的应用 |
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| 引用本文： | 郭建军,黄晓萍,杨一兵.白细胞介素24在抗肿瘤方面的应用[J].江西科学,2011,29(2):182-186. |
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| 作者姓名： | 郭建军 黄晓萍 杨一兵 |
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| 作者单位： | 江西省科学院微生物研究所,江西南昌,330029 |
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| 基金项目： | 江西省科技支撑计划项目，江西省科学院国家级预研项目 |
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| 摘 要： | 人类黑色素瘤分化相关基因-7/白介素-24(MDA-7/IL-24)是近年发现的具有细胞因子特性的抗肿瘤作用的基因,它能够通过膜受体或非受体介导的凋亡途径对多种肿瘤细胞产生杀伤作用,而对正常细胞没有影响.此外,IL-24还具有抑制肿瘤新生血管形成、增强放疗敏感性和免疫调节作用.作为一种具有多种抗肿瘤功能的细胞因子IL-...
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| 关 键 词： | 白细胞介素类24 细胞凋亡 肿瘤抑制 |
Interleukin-24 and its Tumor Gene Therapy |
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| GUO Jian-jun,HUANG Xiao-ping,YANG Yi-bing.Interleukin-24 and its Tumor Gene Therapy[J].Jiangxi Science,2011,29(2):182-186. |
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| Authors: | GUO Jian-jun HUANG Xiao-ping YANG Yi-bing |
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| Institution: | (Institute of Microbiology,Jiangxi Academy of Sciences,Jiangxi Nanchang 330029 PRC) |
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| Abstract: | The melanoma differentiation-associated gene-7/interleukin-24（MDA-7/IL-24） is a novel candidate of tumor suppressor.IL-24 has been found to display ubiquitous anti-tumor biological properties：inducing tumor cell apoptosis,inhibiting angiogenesis and enhancing the sensitivity of radiotherapy,but having no damage to the normal cells.As a multifunctional anti-tumor cytokine,IL-24has been confirmed of the anti-tumor effect in the phase Ⅱ clinical trial,and it becomes a potential new weapon for tumor gene therapy.These demonstrate the potential therapeutic effects of Ad-IL-24 in human cancer. |
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| Keywords: | Interleukins 24 Apoptosis Tumor suppressor |
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