苦物质引起去甲肾上腺素预收缩的大鼠主动脉平滑肌舒张的作用机理研究

为研究苦物质舒张预收缩的大鼠胸主动脉平滑肌的作用机制,以测定肌张力为主要手段,结合多种细胞信号通路阻断剂研究了苦物质的作用通路.结果表明:苦物质对于去甲肾上腺素介导的大鼠胸主动脉的收缩具有高效、快速的舒张作用,此舒张作用与IP3受体和L型钙通道的阻断密切相关.故以氯喹和苦精为代表的苦物质因对血管平滑肌具有良好的舒张作用,有望成为针对高血压等血管相关疾病的新的治疗药物.     

Caffeine as a psychomotor stimulant: mechanism of action

The popularity of caffeine as a psychoactive drug is due to its stimulant properties, which depend on its ability to reduce adenosine transmission in the brain. Adenosine A₁ and A_2A receptors are expressed in the basal ganglia, a group of structures involved in various aspects of motor control. Caffeine acts as an antagonist to both types of receptors. Increasing evidence indicates that the psychomotor stimulant effect of caffeine is generated by affecting a particular group of projection neurons located in the striatum, the main receiving area of the basal ganglia. These cells express high levels of adenosine A_2A receptors, which are involved in various intracellular processes, including the expression of immediate early genes and regulation of the dopamine- and cyclic AMP-regulated 32-kDa phosphoprotein DARPP-32. The present review focuses on the effects of caffeine on striatal signal transduction and on their involvement in caffeine-mediated motor stimulation.Received 8 July 2003; received after revision 7 September 2003; accepted 6 October 2003     

KTP-YAG激光胸外科应用125例

目的：总结ＫＴＰ－ＹＡＧ波长激光在临床胸外科手术中的应用。方法：在１２５例共１０个病的普通胸外科手术中，选用不同波长和功率的ＫＴＰ－ＹＡＧ激光，作用不同组织的不同深度，起切割、止血、凝固或汽化的作用。结果：手术过程顺利，术后并发症２例（１．６％），为胸腔积液和肺漏气各１例，全组无死亡病例，术后胸腔引流量１２０－３１０mL，平均２１０mL，胸腔引流管留置时间２０－５２h，平均２７h。结论ＫＴＰ－ＹＡＧ激光用于胸外科手术是安全有效，具有缩短手术时间、减少出血量和提高癌肿切除机率的优点。     

Substance P-like immunoreactivity in the frog dorsal root ganglia

Summary The distribution of substance P-like immunoreactivity was studied in the thoracic dorsal root ganglia of the frogRana esculenta by immunohistochemistry. Substance P-like immunoreactivity was contained in approximately 50% of primary sensory neurons. The immunoreactive fibers arising from the cell bodies are collected in small bundles within the ganglia neuropil before entering the central and peripheral roots.     

Dick氏内固定器治疗胸腰椎骨折脱位并脊髓损伤

为寻求和解决胸腰椎骨折脱位并脊髓损伤的有效疗法,用DICk氏内固定器治疗53例患者,并随访．对临床资料进行总结分析。结果表明,Dick氏内固定系统符合脊柱的生物力学原理,可使固定节段具有高度的内在稳定性,且具有操作简便、安全、短节段固定,合并症少等优点。     

基底神经节与运动控制的研究进展

基底神经节对于随意运动的发起和执行设计具有重要的作用,本文通过查阅分析相关的文献资料,综述了目前关于基底神经节各通路核团在运动控制中的功能作用,并展望进一步研究基底神经节．丘脑．皮层通路的环路工作机制,为今后运动神经控制的研究工作提供一些参考．     

多发性肋骨骨折手术治疗临床分析

目的探讨镍钛记忆合金环抱式肋骨接骨板治疗多发肋骨骨折的临床效果,并分析其临床应用价值。方法以多发性肋骨骨折患者41例作为手术组,给予镍钛记忆合金环抱器内固定治疗;20例作为保守组给予保守手术治疗,比较两组的效果。结果治疗组总有效率为100％,对照组为73.3％,而且治疗组患者的平均住院时间、骨折愈合时间、疼痛时间、下床活动时间明显短于保守组,两组比较差异具有统计学意义（P〈0．05）。结论采用镍钛记忆合金环抱器内固定治疗多发性肋骨骨折效果显著,具有操作简单、痛苦小、住院时间短及并发症发生率低等优点,值得临床推广应用。     

柞蚕幼虫在体胸神经节自发放电活动的观察

本文以柞蚕五龄幼虫为材料,运用微电极电生理技术,以胞外记录的方法,记录了柞蚕虫在体胸神经节的自发放电活动．结果,柞蚕幼虫胸神经节胞外自发放电有三种形式慢节律单个放电、簇状放电及连续放电．     

Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?

Approximately 60% of subjects with schizophrenia present minor neurological signs (neurological soft signs, NSS), which include abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cog...     

氟尿嘧啶植入剂经皮穿刺胸腔内给药治疗晚期肺癌合并恶性胸腔积液20例

目的：观察氟尿嘧啶植入剂（中人氟安）在晚期肺癌合并恶性胸腔积液治疗中的疗效及毒副作用。方法：20例患者常规胸腔穿刺尽量抽净恶性胸腔积液后胸腔内植入氟尿嘧啶植入剂（中人氟安）1000mg。结果：总有效率70％,未见明显毒副作用（0度～11度）,其不良反应主要为药源性发热、疼痛反应、白细胞下降。结论：氟尿嘧啶植入剂（中人氟安）胸腔内植入对控制恶性胸腔积液疗效可靠,未见明显毒副作用,使用安全,值得临床推广应用和进一步验证。